RIPK2/MKK7/c-Myc Signals as a Target to Stop Prostate Cancer from Spreading
Official title: RIPK2/MKK7/c-Myc Signaling as a Therapeutic Target in Prostate Cancer Metastasis
Funded at State University New York Stony Brook · NIH-11332412 · Data updated 2026-11-12
This grant tests a new way to stop prostate cancer from spreading by blocking a signaling pathway involving RIPK2, MKK7, and c-Myc.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 18, 2022 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $418,288 |
| NIH project number | 5R01CA266694-05 |
| Project ID | NIH-11332412 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with advanced or metastatic prostate cancer who could benefit from therapies targeting RIPK2-related pathways.
✕Less likely to help
Patients whose cancer does not rely on the RIPK2/MKK7/c-Myc signaling axis may see little or no benefit.
What this research studies
Prostate cancer that spreads to other parts of the body is very hard to treat, so the team will study a specific signaling pathway to see if turning it off can reduce metastasis. They will use analyses of patient-derived data and perform lab experiments to understand how RIPK2 influences cancer cell invasion and metastasis. The research includes testing inhibitors that target RIPK2 and examining how this affects cancer cells in vitro and in animal models. The goal is to identify how these signals drive metastasis and to uncover actionable targets for new therapies.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or delay metastasis in men with prostate cancer.
How similar studies have gone: Prior studies show that targeting RIPK2 can reduce invasion and metastasis in prostate cancer models, supporting potential translational value.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Yang, Wei — State University New York Stony Brook
- Study coordinator: Yang, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.