Lipoylation and bone metastasis in prostate cancer: paving the way for new treatments
Official title: Deciphering the Significance of Lipoylation in Prostate Cancer Bone Metastasis to Develop Innovative Therapeutics
Funded at University of Mississippi Med Ctr · NIH-11343531 · Data updated 2026-11-12
A study in men with advanced prostate cancer will explore how a chemical process called lipoylation influences cancer spreading to bone and whether this could lead to new therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | July 13, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $517,920 |
| NIH project number | 1R01CA311683-01 |
| Project ID | NIH-11343531 on NIH RePORTER |
Who could benefit from this research
✓Could help
American men with advanced prostate cancer and bone metastases or those at high risk for bone metastasis.
✕Less likely to help
Patients without prostate cancer or without bone metastases are unlikely to benefit.
What this research studies
This project focuses on how lipoylation and copper-related cell death affect prostate cancer that has spread to bone. Researchers will investigate the bone tumor environment and how it interacts with androgen receptor therapies to drive metastasis. Using patient data and laboratory experiments, they aim to identify targets that could stop or slow bone metastases and test potential therapeutic approaches. The work builds on preliminary findings about FDX1 and lipoylation balance in bone-metastatic disease.
Why it matters
Potential benefit: If successful, the research could reveal new targets for treating bone metastases in prostate cancer and inform the development of novel therapies.
How similar studies have gone: Preliminary data suggest a link between lipoylation, FDX1, and metastasis, but direct clinical validation is ongoing.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Siddiqui, Jawed a — University of Mississippi Med Ctr
- Study coordinator: Siddiqui, Jawed a
Related research
Other NIH-funded projects on the same topics.
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PMN-MDSCs in bone metastasis of prostate cancer
A study in people with advanced prostate cancer bone metastases is exploring how immune-suppressing cells in the bone environment may limit current therapies and how targeting them could help.
-
Personalized Metastasis-Directed Therapy for Prostate Cancer with Imaging and Biopsy Boost
A large North American trial will test whether targeted radiation to metastases helps men with a specific type of prostate cancer and uses biomarker tests and imaging to tailor treatment.
-
Understanding how prostate cancer spreads to bone and stays dormant
Researchers are studying how prostate cancer moves to bone, why it becomes deadly, and how some cancer cells lie dormant before potentially causing trouble.
-
Understanding how tumor neighbors help prostate cancer spread and resist therapy
Researchers are studying how the tumor environment around prostate cancer cells promotes spread and resistance to common therapies, with a focus on a protein called ASPN.
-
RIPK2/MKK7/c-Myc Signals as a Target to Stop Prostate Cancer from Spreading
This grant tests a new way to stop prostate cancer from spreading by blocking a signaling pathway involving RIPK2, MKK7, and c-Myc.
-
Understanding how prostate cancer spreads to bone and why it likes bone
A major NIH grant is funding research to uncover why prostate cancer cells spread to bone and how they grow there, using a mouse model that mirrors human bone metastasis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.