Right heart muscle mechanics in pulmonary hypertension with heart failure

Who could benefit from this research

What this research studies

This project looks at how right ventricular heart muscle cells behave in patients with HFrEF and pulmonary hypertension. By measuring how these cells generate force during calcium activity and movement, the team aims to find better ways to identify early dysfunction during exercise. They will examine mechanisms linking myosin function to the heart’s ability to ramp up its force, hoping to connect cellular findings to clinical tests. The study builds on prior work in related patient groups and seeks to translate cellular insights into improved patient monitoring and treatment decisions.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Hsu, Steven — Johns Hopkins University
• Study coordinator: Hsu, Steven

Related research

Other NIH-funded projects on the same topics.

• Non-invasive, automated heart health checker for early heart failure and pulmonary hypertension

  A new non-invasive device platform aims to measure four key heart-hemodynamics (EF, CO, PAP, PCWP) safely at home or in basic clinics to help people at risk of heart failure or pulmonary hypertension.

  NIH research Sensydia Corporation · Los Angeles, United States · NIH-11322000

• Understanding heart muscle function in patients with heart failure and pulmonary hypertension

  This study is looking at how well the right side of the heart works in people with heart failure and high blood pressure in the lungs, especially during exercise, to find out more about problems that doctors might not usually catch, which could help improve how we diagnose and treat these conditions.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11093558

• A non-invasive tool to assess heart function and risk of heart failure.

  This study is working on a new, easy-to-use tool that can safely check how well your heart is working without any invasive procedures, making it especially helpful for people at risk of heart failure or pulmonary hypertension.

  NIH research Sensydia Corporation · Los Angeles, United States · NIH-10953826

• Using Metformin to Treat Pulmonary Hypertension in Heart Failure Patients

  This study is looking at how the diabetes medication metformin might help older patients with heart failure and high blood pressure in the lungs, especially those with metabolic syndrome, to see if it can improve their heart and lung function.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10460583

• Understanding how CD4 T cells fuel schistosomiasis-related lung disease

  A study explores how specific immune cells and inflammatory signals in schistosomiasis may contribute to pulmonary hypertension in people affected by the disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606580

• CD4 T Cells, Schistosoma, and Pulmonary Hypertension: Understanding How Immune Cells Drive Disease

  A human-health focused study uses a mouse model and human samples to explore how immune cells and inflammation may contribute to a lung blood vessel disease linked to schistosomiasis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606579

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.