Understanding heart muscle function in patients with heart failure and pulmonary hypertension
Official title: Myocyte Mechanics of Right Ventricular Contractile Failure in Pulmonary Hypertension due to Heart Failure with Reduced Ejection Fraction
Funded at Johns Hopkins University · NIH-11093558 · Data updated 2026-11-12
This study is looking at how well the right side of the heart works in people with heart failure and high blood pressure in the lungs, especially during exercise, to find out more about problems that doctors might not usually catch, which could help improve how we diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $638,556 |
| NIH project number | 5R01HL172830-02 |
| Project ID | NIH-11093558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with reduced ejection fraction and pulmonary hypertension.
✕Less likely to help
Patients without heart failure or pulmonary hypertension may not benefit from this research.
What this research studies
This research investigates how the heart's right ventricle functions in patients suffering from heart failure with reduced ejection fraction and pulmonary hypertension. By measuring specific contractile properties of heart muscle cells during exercise, the study aims to identify dysfunction that is often missed by current clinical assessments. The researchers will explore the mechanisms behind these dysfunctions, particularly focusing on how myosin proteins affect heart muscle performance. This approach could lead to improved diagnostic tools and treatment strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for patients with heart failure and pulmonary hypertension.
How similar studies have gone: Previous studies have shown promise in understanding heart muscle dysfunction in similar patient populations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Hsu, Steven — Johns Hopkins University
- Study coordinator: Hsu, Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.