Understanding heart muscle function in patients with heart failure and pulmonary hypertension
Myocyte Mechanics of Right Ventricular Contractile Failure in Pulmonary Hypertension due to Heart Failure with Reduced Ejection Fraction
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11093558
This study is looking at how well the right side of the heart works in people with heart failure and high blood pressure in the lungs, especially during exercise, to find out more about problems that doctors might not usually catch, which could help improve how we diagnose and treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11093558 on ClinicalTrials.gov |
What this research studies
This research investigates how the heart's right ventricle functions in patients suffering from heart failure with reduced ejection fraction and pulmonary hypertension. By measuring specific contractile properties of heart muscle cells during exercise, the study aims to identify dysfunction that is often missed by current clinical assessments. The researchers will explore the mechanisms behind these dysfunctions, particularly focusing on how myosin proteins affect heart muscle performance. This approach could lead to improved diagnostic tools and treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with reduced ejection fraction and pulmonary hypertension.
Not a fit: Patients without heart failure or pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for patients with heart failure and pulmonary hypertension.
How similar studies have performed: Previous studies have shown promise in understanding heart muscle dysfunction in similar patient populations, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSU, STEVEN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: HSU, STEVEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.