Improving sleep and circadian rhythms in critically ill patients in the ICU
Official title: Reestablishing Sleep and Circadian Alignment in Medically Critically Ill Patients via a Mechanistic Randomized Controlled Trial of an ICU Sleep Chronobundle (ReAlign-ICU)
Funded at Yale University · NIH-10892022 · Data updated 2026-11-12
This study is testing a new way to help patients in the ICU get better sleep and feel more in sync with day and night, which could improve their health while they recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 21, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $782,455 |
| NIH project number | 5R01HL163659-02 |
| Project ID | NIH-10892022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients admitted to the ICU who are experiencing sleep and circadian disruptions.
✕Less likely to help
Patients who are not critically ill or those who do not have significant sleep disturbances may not benefit from this research.
What this research studies
This research investigates a new treatment approach to help critically ill patients in the ICU by addressing their disrupted sleep and circadian rhythms. The study will implement a bundled strategy that combines various methods to promote better sleep and align biological clocks with the day-night cycle. By focusing on the timing, duration, and quality of sleep, the research aims to improve overall health outcomes for patients who are at high risk for complications due to sleep disruption. Patients will be monitored closely to assess the effectiveness of these interventions in real-time.
Why it matters
Potential benefit: If successful, this research could significantly enhance recovery and overall health outcomes for critically ill patients by improving their sleep quality and circadian alignment.
How similar studies have gone: While ICU sleep promotion bundles have had limited success in the past, this research aims to innovate by integrating circadian principles, making it a novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Knauert, Melissa P — Yale University
- Study coordinator: Knauert, Melissa P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.