Comparative modeling to guide colorectal cancer screening and care
Official title: Comparative Modeling to Inform Colorectal Cancer Control Strategies
Funded at Utah State Higher Education System--University of Utah · NIH-11495363 · Data updated 2026-11-12
A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $929,299 |
| NIH project number | 1U01CA319117-01 |
| Project ID | NIH-11495363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older in the US, particularly those facing access-to-care barriers or considering CRC screening options.
✕Less likely to help
Individuals without access barriers or those not considering CRC screening may experience no direct benefit.
What this research studies
This project uses comparative modeling to simulate how different CRC screening strategies and care pathways perform under real-world conditions. It aims to understand how geographic and resource barriers shape who gets screened and treated, as well as how rising early-onset CRC might change future outcomes. The work will incorporate new screening tests and biomarker-guided treatments to estimate benefits, harms, and costs for diverse populations. The model outputs will help policymakers and healthcare systems choose strategies that reduce mortality while considering access and resources.
Why it matters
Potential benefit: If successful, the work could inform better CRC screening and treatment strategies that improve access and outcomes for people at risk or living with colorectal cancer.
How similar studies have gone: Previous modeling efforts have shown value in guiding screening policies, though this project addresses evolving technologies and early-onset CRC.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Inadomi, John Matthew — Utah State Higher Education System--University of Utah
- Study coordinator: Inadomi, John Matthew
Related research
Other NIH-funded projects on the same topics.
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Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Ceramides and how they affect metabolism and colorectal cancer in adults
A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.
-
Automated point-of-care DNA methylation test for colorectal cancer in LMICs
A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.
-
Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation
A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.
-
Making colorectal cancer screening easier and more likely to happen
This project uses default options, simpler choices, and direct outreach to help average-risk adults who are overdue complete colorectal cancer screening with colonoscopy or stool tests.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.