NIH-funded research R01 grant

Radiomic markers from 3D mammography to predict breast cancer risk across diverse women

Official title: Radiomic phenotypes for invasive and advanced breast cancer

Funded at Mayo Clinic Rochester · NIH-11386848 · Data updated 2026-11-12

A Mayo Clinic team is testing advanced computer-derived features from 3D mammograms to improve predicting who will develop breast cancer, including diverse groups of women.

More Breast Cancer research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMayo Clinic Rochester
NIH-funded
Lab location1 site (Rochester, United States)
Project startJune 1, 2026
Project endMay 31, 2031
Funding year2026
Award (this year)$722,914
NIH project number1R01CA305931-01A1
Project IDNIH-11386848 on NIH RePORTER

Who could benefit from this research

Could help

Women undergoing routine mammography, including diverse racial/ethnic backgrounds.

Less likely to help

Women with average risk or those not undergoing standard mammography may not directly benefit.

What this research studies

This project uses 3D mammography data to extract radiomic features that describe breast tissue in more detail than standard density measures. The goal is to identify radiomic phenotypes that predict future invasive breast cancer and interval cancers across racial groups. By focusing on 3D imaging and AI-based analysis, the study aims to create more accurate risk models that could guide screening and prevention for women who undergo routine mammograms. The research team will validate these features across diverse populations, with an emphasis on representative racial and ethnic groups.

Why it matters

Potential benefit: If successful, the work could lead to more individualized screening plans and earlier detection for women at higher risk.

How similar studies have gone: Previous work showed radiomic patterns can relate to breast cancer risk in some groups, but this project extends validation to 3D mammography and diverse populations.

Where this research is happening

  • Mayo Clinic Rochester
    Rochester, United States
    Active

Researchers

  • Principal investigator: Vachon, Celine M — Mayo Clinic Rochester
  • Study coordinator: Vachon, Celine M

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.