Radiomic markers from 3D mammography to predict breast cancer risk across diverse women
Official title: Radiomic phenotypes for invasive and advanced breast cancer
Funded at Mayo Clinic Rochester · NIH-11386848 · Data updated 2026-11-12
A Mayo Clinic team is testing advanced computer-derived features from 3D mammograms to improve predicting who will develop breast cancer, including diverse groups of women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $722,914 |
| NIH project number | 1R01CA305931-01A1 |
| Project ID | NIH-11386848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women undergoing routine mammography, including diverse racial/ethnic backgrounds.
✕Less likely to help
Women with average risk or those not undergoing standard mammography may not directly benefit.
What this research studies
This project uses 3D mammography data to extract radiomic features that describe breast tissue in more detail than standard density measures. The goal is to identify radiomic phenotypes that predict future invasive breast cancer and interval cancers across racial groups. By focusing on 3D imaging and AI-based analysis, the study aims to create more accurate risk models that could guide screening and prevention for women who undergo routine mammograms. The research team will validate these features across diverse populations, with an emphasis on representative racial and ethnic groups.
Why it matters
Potential benefit: If successful, the work could lead to more individualized screening plans and earlier detection for women at higher risk.
How similar studies have gone: Previous work showed radiomic patterns can relate to breast cancer risk in some groups, but this project extends validation to 3D mammography and diverse populations.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Vachon, Celine M — Mayo Clinic Rochester
- Study coordinator: Vachon, Celine M
Related research
Other NIH-funded projects on the same topics.
-
Improving how the immune system fights advanced breast cancer by relieving tumor pressure
A breast cancer treatment study tests whether a common blood pressure drug (losartan) can help immune cells get into tumors and work better with immunotherapy.
-
Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer
This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.
-
Personalizing estrogen therapy for ER-positive breast cancer
This project finds how the hormone estrogen can kill certain ER-positive breast cancers and how to tell which patients will benefit.
-
Longer overnight fasting and exercise to reduce fatigue in women with hormone receptor–positive advanced breast cancer
This project will see if longer overnight fasting and regular exercise help women with hormone receptor–positive advanced breast cancer feel less fatigued and improve their quality of life.
-
FFNP-PET scans to predict hormone therapy response in advanced ER-positive breast cancer
This project uses a special PET scan called FFNP to find which people with ER-positive, HER2-negative advanced breast cancer are likely to benefit from hormone (endocrine) therapies.
-
Monitoring breast cancer treatment using blood tests for tumor DNA
This study is looking at how to better treat people with early and locally advanced breast cancer by checking for tiny bits of cancer DNA in their blood, which could help doctors spot any remaining cancer sooner and tailor treatments to each patient, reducing the chance of unnecessary therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.