Preventing nerve cell death in multiple sclerosis
Official title: Inhibition of MIF nuclease-mediated parthanatos prevents neuron and oligodendrocyte death in the context of multiple sclerosis
Funded at Johns Hopkins University · NIH-10999299 · Data updated 2026-11-12
This study is looking at how certain brain cells die in people with multiple sclerosis, focusing on a unique type of cell death, to find new ways to help protect these important cells and improve treatments for MS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 4, 2023 |
| Project end | June 3, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS132520-02 |
| Project ID | NIH-10999299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing progressive forms of the disease.
✕Less likely to help
Patients with other neurological conditions unrelated to multiple sclerosis may not benefit from this research.
What this research studies
This research investigates how certain nerve cells and supporting cells in the brain die in multiple sclerosis (MS), a disease affecting many young adults. The study focuses on a specific type of cell death called parthanatos, which is different from the more commonly understood apoptosis. By using advanced biological models, the researchers aim to uncover the mechanisms behind this cell death to identify new treatment targets. The goal is to develop therapies that can prevent the degeneration of these critical cells in patients with MS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent nerve cell death in multiple sclerosis, potentially improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in targeting cell death pathways in neurological diseases, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Mace, Jackson — Johns Hopkins University
- Study coordinator: Mace, Jackson
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.