Predicting PTLD risk and treatment response in transplant patients using EBV and host immune factors
Official title: Epstein-Barr Virus positive post-transplant lymphoproliferative disorders: identifying viral and host variables to predict risk and therapeutic responses
Funded at Ohio State University · NIH-11279989 · Data updated 2026-11-12
Aimed at people who have had organ transplants, this project looks for viral and immune clues to predict who might develop PTLD and how well treatment might work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 13, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $366,965 |
| NIH project number | 1R01CA308586-01 |
| Project ID | NIH-11279989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Solid organ transplant recipients at risk for or diagnosed with PTLD, and those with EBV-related PTLD features.
✕Less likely to help
Patients without PTLD or EBV-associated risk may not directly benefit.
What this research studies
This project studies post-transplant lymphoproliferative disorder (PTLD), a serious cancer risk after organ transplant, and how Epstein-Barr Virus-related changes and host immune factors influence outcomes. By studying EBV status, immune cell patterns, and biomarker signals from patient samples, the team seeks to identify factors that predict PTLD risk and treatment response. The approach uses existing patient biorepositories and cohorts to explore risk factors, monitoring methods, and prevention/therapy options. The goal is to translate findings into better risk stratification and more effective management for transplant patients facing PTLD.
Why it matters
Potential benefit: If successful, patients could benefit from improved risk prediction and more personalized prevention and treatment strategies for PTLD.
How similar studies have gone: Preliminary data from multiple cohorts support the relevance of immune network dysregulation in PTLD; translational confirmation is needed.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Baiocchi, Robert Alan — Ohio State University
- Study coordinator: Baiocchi, Robert Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.