Precision cardiovascular profiling in South Asians to improve ASCVD prediction
Official title: Precision Cardiovascular Diseases Phenotyping and Pathophysiological Pathways in the CARRS Cohort (Precision-CARRS)
Funded at Emory University · NIH-11617877 · Data updated 2026-11-12
A study in the CARRS cohort aims to refine how we predict and prevent heart disease in young to middle-aged South Asians by using detailed phenotyping and multi-omics.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 15, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $244,040 |
| NIH project number | 3P01HL154996-05S2 |
| Project ID | NIH-11617877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of South Asian background (≥20 years old) enrolled in or similar to the NHLBI-funded CARRS cohort, with ongoing follow-up.
✕Less likely to help
Individuals outside the South Asian population or those not represented in the cohort may not directly benefit from these findings.
What this research studies
This project builds on the NHLBI-supported CARRS cohort of over 21,000 South Asians aged 20+ with long-term follow-up and a large biorepository. Researchers will add in-depth clinical and subclinical cardiovascular measurements, repeated proteomic and untargeted omics analyses, and real-time data on health behaviors to understand early drivers of ASCVD and heart failure. By extending follow-up by five years, the study expects many more ASCVD events and rich data to link genetics, environment, and biology to disease risk. The goal is to create more personalized risk predictions and prevention strategies for this high-risk population.
Why it matters
Potential benefit: If successful, patients could receive more accurate and earlier risk assessment and tailored prevention strategies for ASCVD and heart failure.
How similar studies have gone: Prior cohorts have shown that multi-omics and longitudinal phenotyping can improve ASCVD risk prediction, but this project expands this approach in a high-risk, understudied population.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
Other NIH-funded projects on the same topics.
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Precision Cardiovascular Diseases in the South Asian CARRS Cohort
This grant aims to improve how heart disease risk is predicted and managed for South Asian adults by adding detailed health measurements and real-time behavior data to a large ongoing cohort.
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Precision cardiovascular disease profiling in South Asians (CARRS)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.