Precision cardiovascular disease profiling in South Asians (CARRS)
Official title: Precision Cardiovascular Diseases Phenotyping and Pathophysiological Pathways in the CARRS Cohort (Precision-CARRS)
Funded at Emory University · NIH-11617878 · Data updated 2026-11-12
A large study from Emory will create a detailed, personalized portrait of heart disease risk and early disease markers in South Asian adults to improve future prevention.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 15, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $29,766 |
| NIH project number | 3P01HL154996-05S3 |
| Project ID | NIH-11617878 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of South Asian descent aged 20 and older who are enrolled in or eligible for the CARRS cohort and willing to participate in extended follow-up and additional phenotyping.
✕Less likely to help
Individuals outside the South Asian population or those not participating in long-term follow-up may not benefit.
What this research studies
This project expands the NHLBI-supported CARRS cohort of over 21,000 South Asians aged 20 and older by adding deeper heart disease phenotyping, repeated protein and multi-omics measurements, and real-time health behavior tracking. By extending follow-up by about five years, the study aims to capture hundreds of ASCVD events and many cases of clinical disease to better understand how genetics, environment, and behavior shape risk. The work will leverage stored biospecimens (about 360,000 samples) and high-retention follow-up to build a precise, early-career risk model that can guide prevention in this high-risk population. The goal is to move from broad risk estimates to personalized prediction and prevention strategies for ASCVD and heart failure.
Why it matters
Potential benefit: If successful, patients could receive more accurate risk assessments and tailored prevention plans to reduce heart attack and stroke risk.
How similar studies have gone: The study builds on a large existing cohort with high retention and proven data resources, suggesting strong potential for meaningful findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
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Precision Cardiovascular Diseases in the South Asian CARRS Cohort
This grant aims to improve how heart disease risk is predicted and managed for South Asian adults by adding detailed health measurements and real-time behavior data to a large ongoing cohort.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.