Precision cardiovascular disease profiling in South Asian adults
Official title: Precision Cardiovascular Diseases Phenotyping and Pathophysiological Pathways in the CARRS Cohort (Precision-CARRS)
Funded at Emory University · NIH-11617876 · Data updated 2026-11-12
This grant aims to improve how we predict and prevent heart disease in adults, using detailed measurements and real-time behavior data from a large South Asian cohort.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 15, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $426,183 |
| NIH project number | 3P01HL154996-05S1 |
| Project ID | NIH-11617876 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of South Asian descent (≥20 years) who are part of or similar to the CARRS cohort and have ongoing follow-up opportunities for ASCVD risk factors and related outcomes.
✕Less likely to help
Individuals not at elevated ASCVD risk or those not eligible for long-term follow-up may see limited direct benefit.
What this research studies
Precision-CARRS seeks to move from broad, late-stage risk thinking to personalized prediction for ASCVD and heart failure by studying genetic, environmental, behavioral, and molecular factors. The project builds on the NHLBI-supported CARRS cohort of over 21,000 South Asians aged 20 and older, with extensive follow-up and a large biorepository. Researchers will add deep clinical and subclinical heart disease phenotyping, regular protein and omics profiling, and real-time health behavior monitoring to extend follow-up by about five years. This could reveal how early-life factors and daily exposures shape disease risk and progression in a high-risk population. The study aims to generate insights that could guide earlier, more precise prevention and treatment approaches in ASCVD and HF.
Why it matters
Potential benefit: If successful, patients could receive more personalized prevention strategies and earlier interventions for ASCVD and heart failure.
How similar studies have gone: Previous cohorts with deep phenotyping and multi-omics have improved risk prediction and understanding of ASCVD pathways, supporting a promising path here.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Narayan, Kabayam M Venkat — Emory University
- Study coordinator: Narayan, Kabayam M Venkat
Related research
Other NIH-funded projects on the same topics.
-
Precision Cardiovascular Diseases in the South Asian CARRS Cohort
This grant aims to improve how heart disease risk is predicted and managed for South Asian adults by adding detailed health measurements and real-time behavior data to a large ongoing cohort.
-
Precision cardiovascular disease profiling in South Asians (CARRS)
A large study from Emory will create a detailed, personalized portrait of heart disease risk and early disease markers in South Asian adults to improve future prevention.
-
Precision cardiovascular profiling in South Asians to improve ASCVD prediction
A study in the CARRS cohort aims to refine how we predict and prevent heart disease in young to middle-aged South Asians by using detailed phenotyping and multi-omics.
-
Making healthier sodium and potassium choices in U.S. communities
A large-scale effort uses real-world data to test local policies that encourage healthier sodium and potassium intake to reduce heart disease risk.
-
ENCORE: Electronic Cardiovascular Consults for Rural Clinics
A national study will test how electronic consultations between primary care providers in rural clinics and heart specialists affect care for people with heart disease.
-
Immunity and heart-kidney health in adults
A large, patient-focused program will study how immune cells contribute to high blood pressure and autoimmune kidney and blood vessel disease in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.