Precise imaging to guide thrombectomy for posterior circulation strokes
Official title: PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)
Funded at Stanford University · NIH-11345266 · Data updated 2026-11-12
A study at Stanford will test whether special brain imaging helps doctors decide which patients with rare posterior circulation strokes should get thrombectomy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2021 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,332,991 |
| NIH project number | 5R01NS121720-05 |
| Project ID | NIH-11345266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years or older with acute ischemic stroke due to vertebral or basilar artery occlusion and within 24 hours of symptom onset.
✕Less likely to help
Patients without suitable perfusion imaging patterns or outside the treatment window may not benefit from the imaging-guided approach.
What this research studies
This project follows adults with acute stroke caused by vertebral or basilar artery blockage to see if perfusion imaging before thrombectomy can identify who will benefit most. Using CT or MRI perfusion, researchers will look for imaging patterns that predict good outcomes after the clot-removing procedure. Participants will receive the standard care of thrombectomy, with imaging data guiding treatment decisions. The goal is to improve outcomes and reduce disability for this high-risk stroke group.
Why it matters
Potential benefit: If successful, this approach could tailor treatment to patients with posterior circulation strokes, potentially improving recovery and reducing disability.
How similar studies have gone: Previous work in anterior circulation strokes showed benefits from perfusion imaging; this study extends the question to posterior circulation strokes.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Albers, Gregory W — Stanford University
- Study coordinator: Albers, Gregory W
Related research
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Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
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Improving treatment for severe strokes using advanced techniques
This study is looking at how well a special procedure called endovascular thrombectomy (EVT) works for people having a stroke caused by blocked blood vessels, and it aims to find out if new tools and treatments can help even more patients recover better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.