NIH-funded research R01 grant

Practical tools to boost cognitive screening for older adults with diabetes

Official title: A Pragmatic Clinical Trial to Improve Screening for Cognitive Impairment in Older Adults with Diabetes

Funded at Johns Hopkins University · NIH-11430899 · Data updated 2026-11-12

A Johns Hopkins team is testing a practical way to screen for cognitive problems in people 65 and older with diabetes using new language-model tools and a real-world clinical trial.

More Cognitive Impairment research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University
NIH-funded
Lab location1 site (Baltimore, United States)
Project startSeptember 15, 2026
Project endAugust 31, 2031
Funding year2026
Award (this year)$680,637
NIH project number1R01AG103426-01
Project IDNIH-11430899 on NIH RePORTER

Who could benefit from this research

Could help

Adults aged 65 and older with diabetes who are receiving care in participating healthcare systems.

Less likely to help

Older adults without diabetes or those not eligible for screening may not benefit from this intervention.

What this research studies

This project aims to create and validate smart tools that can spot cognitive impairment in older adults with diabetes by analyzing electronic health records with advanced language models. It will test a clinical decision support system in everyday healthcare settings to help doctors screen for cognitive issues, diagnose more accurately, and manage care. The approach focuses on scalable, system-wide changes to improve screening rates and outcomes for seniors living with diabetes and at risk for dementia. The study is designed to fit into routine visits and use real-world data to guide practical improvements. By combining NLP technology with pragmatic trial design, it seeks to make screening more reliable and patient-centered.

Why it matters

Potential benefit: If successful, the intervention could lead to earlier detection of cognitive problems and better management, reducing complications and improving quality of life for older adults with diabetes.

How similar studies have gone: Previous work suggests that decision-support tools can improve screening practices, but this project tests a scalable approach in a real-world population.

Where this research is happening

  • Johns Hopkins University
    Baltimore, United States
    Active

Researchers

  • Principal investigator: Selvin, Elizabeth — Johns Hopkins University
  • Study coordinator: Selvin, Elizabeth

Related research

Other NIH-funded projects on the same topics.

  • A Blood Test to Understand Memory Changes in Diabetes

    This project explores how a blood test might help us understand and predict memory changes in older adults living with diabetes.

    NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-11175378

  • Identifying protein markers that predict cognitive impairment in people with type 2 diabetes

    This study is looking at how type 2 diabetes might affect thinking and memory, and it’s for people with diabetes who want to understand more about their brain health; by checking certain proteins in the blood, researchers hope to find clues that could help spot early signs of cognitive problems.

    NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10951176

  • Investigating how stress in brain cells affects cognitive function in people with type 2 diabetes.

    This study is looking at how stress in brain cells might affect thinking and memory in people with type 2 diabetes, and it hopes to find ways to fix these changes to help improve brain function.

    NIH research Wright State University · Dayton, United States · NIH-10897829

  • How type 2 diabetes affects brain health and dementia risk

    This study is looking at how not managing type 2 diabetes and prediabetes can affect brain health and memory in young adults aged 18 to 45, and it wants to find out if better diabetes management can help keep your mind sharp.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10854563

  • Using blood-based markers to understand cognitive decline in diabetes patients

    This study is looking at how diabetes might affect brain insulin signaling and memory in older adults, using tiny particles from blood to help find early signs of cognitive decline and ways to prevent it.

    NIH research Hennepin Healthcare Research Institute · Minneapolis, United States · NIH-10810540

  • HEARTS hypertension and diabetes care in Guatemala

    This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11645315

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.