Identifying protein markers that predict cognitive impairment in people with type 2 diabetes
Official title: Proteomic markers of risk for cognitive impairment in people with type 2 diabetes
Funded at University of Colorado Denver · NIH-10951176 · Data updated 2026-11-12
This study is looking at how type 2 diabetes might affect thinking and memory, and it’s for people with diabetes who want to understand more about their brain health; by checking certain proteins in the blood, researchers hope to find clues that could help spot early signs of cognitive problems.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $326,797 |
| NIH project number | 1R03AG088803-01 |
| Project ID | NIH-10951176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are at risk for cognitive impairment.
✕Less likely to help
Patients without type 2 diabetes or those who do not have any risk factors for cognitive impairment may not benefit from this research.
What this research studies
This research investigates how type 2 diabetes may lead to cognitive impairment, including conditions like mild cognitive impairment and Alzheimer's disease. By analyzing plasma proteins in individuals with type 2 diabetes, the study aims to uncover molecular mechanisms that contribute to cognitive decline. The approach involves proteomic analyses, which can identify specific proteins that serve as biomarkers for predicting cognitive issues. This could ultimately help in early identification and intervention for those at risk.
Why it matters
Potential benefit: If successful, this research could lead to early detection of cognitive impairment in patients with type 2 diabetes, allowing for timely interventions.
How similar studies have gone: While proteomic approaches have been successful in other areas of research, this specific application to cognitive impairment in type 2 diabetes is relatively novel and underexplored.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Shapiro, Allison Livia Buti — University of Colorado Denver
- Study coordinator: Shapiro, Allison Livia Buti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.