Investigating how stress in brain cells affects cognitive function in people with type 2 diabetes.

Who could benefit from this research

What this research studies

This research explores the relationship between endoplasmic reticulum (ER) stress and cognitive impairment in individuals with type 2 diabetes. It focuses on the axon initial segment (AIS), a crucial part of neurons that can change in structure due to diabetes, potentially leading to cognitive decline. The study aims to understand the cellular mechanisms behind these changes and whether reversing AIS shortening could improve cognitive function. By examining specific pathways involved in ER stress, the research seeks to identify new therapeutic targets for treatment.

Why it matters

Where this research is happening

• Wright State University
  Dayton, United States Active

Researchers

• Principal investigator: Shelby, Jennae Nicolle — Wright State University
• Study coordinator: Shelby, Jennae Nicolle

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10854563

• Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)

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  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11617648

• Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes

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  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11594416

• Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes

  This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11585476

• Personalized use of newer diabetes medicines for Type 2 diabetes

  Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.

  NIH research Purdue University · West Lafayette, United States · NIH-11571362

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.