Investigating how stress in brain cells affects cognitive function in people with type 2 diabetes.
Unfolding the Link Between the Endoplasmic Reticulum, AIS Shortening, and Cognitive Impairment in Type 2 Diabetes
This study is looking at how stress in brain cells might affect thinking and memory in people with type 2 diabetes, and it hopes to find ways to fix these changes to help improve brain function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project ID | NIH-10897829 on NIH RePORTER |
What this research studies
This research explores the relationship between endoplasmic reticulum (ER) stress and cognitive impairment in individuals with type 2 diabetes. It focuses on the axon initial segment (AIS), a crucial part of neurons that can change in structure due to diabetes, potentially leading to cognitive decline. The study aims to understand the cellular mechanisms behind these changes and whether reversing AIS shortening could improve cognitive function. By examining specific pathways involved in ER stress, the research seeks to identify new therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are experiencing cognitive impairment or mild cognitive decline.
Not a fit: Patients without type 2 diabetes or those who do not exhibit cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with type 2 diabetes.
How similar studies have performed: Previous research has indicated that addressing ER stress may reverse cognitive decline in similar conditions, suggesting a promising avenue for this investigation.
Where this research is happening
Dayton, United States
- Wright State University — Dayton, United States (Active)
Researchers
- Principal investigator: Shelby, Jennae Nicolle — Wright State University
- Study coordinator: Shelby, Jennae Nicolle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.