Post-stroke cognitive decline and dementia: understanding and preventing PSCID
Official title: Post-stroke Cognitive Impairment and Dementia
Funded at Ut Southwestern Medical Center · NIH-11382953 · Data updated 2026-11-12
A large NIH project will use real-world data from two million stroke records to better understand how many people develop PSCID and what factors raise that risk, with the goal of guiding prevention and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,461,531 |
| NIH project number | 4R01AG088217-03 |
| Project ID | NIH-11382953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have had a stroke and may develop PSCID, or who are at risk due to vascular conditions, could be part of related analyses.
✕Less likely to help
People without a stroke history or those not at risk for PSCID may see little direct benefit.
What this research studies
This project will combine data from the nation’s largest stroke registry and Medicare records to create a real-world data platform focused on post-stroke cognitive impairment and dementia. Researchers will map how often PSCID occurs, identify risk factors, and examine how vascular health and medications influence outcomes. The study aims to illuminate pathways that lead from stroke to dementia and to support evidence-based prevention and treatment strategies for patients and clinicians. By analyzing real patient data across many hospitals, the work seeks to generate actionable insights for reducing PSCID burden.
Why it matters
Potential benefit: If successful, patients could benefit from clearer prevention strategies and better management of vascular risk factors to reduce PSCID risk.
How similar studies have gone: Preliminary studies using large healthcare data have shown promise in identifying PSCID patterns, but this project aims to create a comprehensive real-world platform.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Xian, Ying — Ut Southwestern Medical Center
- Study coordinator: Xian, Ying
Related research
Other NIH-funded projects on the same topics.
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Understanding and reducing cognitive problems after stroke
A study from the University of Michigan aims to see if simple cognitive activities and sleep improvements can lower the risk of developing vascular cognitive impairment and dementia after stroke.
-
Memory and thinking problems after a stroke
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Improving brain insulin function to help cognitive issues after stroke
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Understanding cognitive impairment and dementia after a stroke
This study is looking at how strokes can lead to memory and thinking problems, especially in people who have had a stroke, and it aims to find out what factors might increase the risk and whether certain medications can help prevent these issues for stroke survivors.
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BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
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Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.