Understanding cognitive impairment and dementia after a stroke
Official title: Post-stroke Cognitive Impairment and Dementia
Funded at Ut Southwestern Medical Center · NIH-10943759 · Data updated 2026-11-12
This study is looking at how strokes can lead to memory and thinking problems, especially in people who have had a stroke, and it aims to find out what factors might increase the risk and whether certain medications can help prevent these issues for stroke survivors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $834,094 |
| NIH project number | 1R01AG088217-01 |
| Project ID | NIH-10943759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a stroke and are at risk of developing cognitive impairment or dementia.
✕Less likely to help
Patients who have not experienced a stroke or do not have any cognitive impairment may not benefit from this research.
What this research studies
This research investigates how strokes contribute to cognitive impairment and dementia, focusing on the prevalence and risk factors associated with post-stroke cognitive impairment and dementia (PSCID). By utilizing a large national stroke registry and Medicare data, the study aims to identify the incidence of PSCID and explore how various vascular risk factors may influence its development. The research will also evaluate the potential effectiveness of medications in preventing PSCID among stroke survivors. This approach aims to provide insights that could lead to better prevention strategies for those affected.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for cognitive impairment and dementia in stroke survivors.
How similar studies have gone: Previous research has shown that understanding vascular contributions to cognitive impairment can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Xian, Ying — Ut Southwestern Medical Center
- Study coordinator: Xian, Ying
Related research
Other NIH-funded projects on the same topics.
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Understanding and reducing cognitive problems after stroke
A study from the University of Michigan aims to see if simple cognitive activities and sleep improvements can lower the risk of developing vascular cognitive impairment and dementia after stroke.
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Post-stroke cognitive decline and dementia: understanding and preventing PSCID
A large NIH project will use real-world data from two million stroke records to better understand how many people develop PSCID and what factors raise that risk, with the goal of guiding prevention and care.
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Memory and thinking problems after a stroke
This project uses hospital and Medicare records to find how often people get memory and thinking problems after a stroke and what raises their risk.
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Improving brain insulin function to help cognitive issues after stroke
This study is looking at how insulin in the brain affects blood vessel health and thinking skills after a stroke, with the goal of finding new ways to help improve brain function for people dealing with memory and thinking problems.
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BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
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Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.