Memory and thinking problems after a stroke
Official title: Post-stroke Cognitive Impairment and Dementia
Funded at Ut Southwestern Medical Center · NIH-11184400 · Data updated 2026-11-12
This project uses hospital and Medicare records to find how often people get memory and thinking problems after a stroke and what raises their risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $795,304 |
| NIH project number | 5R01AG088217-02 |
| Project ID | NIH-11184400 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have had a recent or prior stroke and are represented in hospital registries or Medicare records would be the focus of this work.
✕Less likely to help
People without a history of stroke or without hospital/Medicare records are unlikely to be directly affected by this project.
What this research studies
If I had a stroke, this project would pull together my hospital record and Medicare data along with millions of other stroke records to build a real-world database about post-stroke memory and thinking problems. Researchers will link two million stroke records from over 2,000 U.S. hospitals with claims data to measure how common post-stroke cognitive impairment and dementia are and which risk factors are involved. They will examine cardiovascular conditions and common medications (such as blood pressure medicines, antithrombotics, and statins) to see how these relate to later thinking problems. The effort will create a resource to help clinicians spot high-risk patients and inform strategies to prevent cognitive decline after stroke.
Why it matters
Potential benefit: If successful, this work could help doctors identify stroke survivors at high risk for dementia and shape treatments or prevention strategies to reduce that risk.
How similar studies have gone: Large registry and claims studies have improved understanding of stroke outcomes, but large-scale, focused work specifically on post-stroke dementia is limited and still emerging.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Xian, Ying — Ut Southwestern Medical Center
- Study coordinator: Xian, Ying
Related research
Other NIH-funded projects on the same topics.
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Understanding and reducing cognitive problems after stroke
A study from the University of Michigan aims to see if simple cognitive activities and sleep improvements can lower the risk of developing vascular cognitive impairment and dementia after stroke.
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Post-stroke cognitive decline and dementia: understanding and preventing PSCID
A large NIH project will use real-world data from two million stroke records to better understand how many people develop PSCID and what factors raise that risk, with the goal of guiding prevention and care.
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Improving brain insulin function to help cognitive issues after stroke
This study is looking at how insulin in the brain affects blood vessel health and thinking skills after a stroke, with the goal of finding new ways to help improve brain function for people dealing with memory and thinking problems.
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Understanding cognitive impairment and dementia after a stroke
This study is looking at how strokes can lead to memory and thinking problems, especially in people who have had a stroke, and it aims to find out what factors might increase the risk and whether certain medications can help prevent these issues for stroke survivors.
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BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
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Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.