Placental Hormones and a sugar tag in Gestational Diabetes
Official title: Placental Hormones and O-GlcNAcylation in Gestational Diabetes
Funded at Medical College of Wisconsin · NIH-11377592 · Data updated 2026-11-12
A researcher is studying how placental hormones and a sugar-related modification in the placenta might contribute to gestational diabetes and its impact on mom and baby.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 26, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $328,354 |
| NIH project number | 5R01HD104808-05 |
| Project ID | NIH-11377592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals at risk for or diagnosed with gestational diabetes and their babies may be eligible to contribute through related studies.
✕Less likely to help
Individuals without gestational diabetes or related placental biology questions may not directly benefit from this work.
What this research studies
This project looks at how placental hormones and a sugar-related modification called O-GlcNAcylation change with blood sugar levels during pregnancy. It aims to understand how these changes affect placental function and insulin signaling, which could influence the risk of gestational diabetes progressing to type 2 diabetes later for both mother and child. The study will use existing data and biological samples to explore the link between glucose, placental biology, and hormone secretion. If successful, the findings could guide safer, non-toxic approaches to prevent or treat GDM.
Why it matters
Potential benefit: Could lead to new, safer treatments to prevent or reduce long-term complications of gestational diabetes for mothers and their children.
How similar studies have gone: Prior work suggests placental hormones and glucose-related modifications influence placental function, with potential for new therapies, making this approach promising but still exploratory.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Olivier-Van Stichelen, Stephanie — Medical College of Wisconsin
- Study coordinator: Olivier-Van Stichelen, Stephanie
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A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
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NDPP-MAP: A tailored online-hybrid program to reduce long-term health risks after pregnancy with gestational diabetes
A patient-friendly program adapts a proven diabetes prevention approach to help women who had gestational diabetes lower their risk of type 2 diabetes and heart problems.
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In Vivo Look at Placental Blood Flow in Gestational Diabetes
A non-invasive MRI study in pregnant people with gestational diabetes and those without will map how placental blood vessels work and relate to baby outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.