IGF factors and binding proteins in gestational diabetes and fetal growth
Official title: Impact of insulin-like growth factors and binding proteins on gestational diabetes and fetal growth
Funded at Harvard Pilgrim Health Care, INC. · NIH-11541955 · Data updated 2026-11-12
A study in pregnant people looks at how insulin-like growth factors and their binding proteins affect gestational diabetes and how a baby grows.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project start | September 17, 2018 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $63,696 |
| NIH project number | 3R01HD094150-06A1S1 |
| Project ID | NIH-11541955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals, especially those at risk or diagnosed with gestational diabetes, and their fetuses.
✕Less likely to help
Pregnant people without insulin resistance or GDM may not directly benefit from this research.
What this research studies
This project explores how IGF-related proteins in the placenta influence insulin resistance during late pregnancy and the risk of gestational diabetes. It uses animal models and human data to understand how IGF2 and IGFBP1 may regulate maternal metabolism and fetal growth. The goal is to identify causal roles and potential targets for personalized therapies in insulin resistant GDM. Researchers will combine laboratory experiments with analyses of clinical samples to link placental biology with pregnancy outcomes. Results could lead to more precise care for pregnant people at risk of GDM and abnormal fetal growth.
Why it matters
Potential benefit: Could lead to targeted interventions that improve glucose control and fetal growth in pregnancies affected by insulin resistance.
How similar studies have gone: Prior work has linked IGFBP1 and IGF2 to metabolic regulation in pregnancy, supporting further exploration in humans and animals.
Where this research is happening
-
Harvard Pilgrim Health Care, INC.
Canton, United States Active
Researchers
- Principal investigator: Hivert, Marie-France — Harvard Pilgrim Health Care, INC.
- Study coordinator: Hivert, Marie-France
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.