NIH-funded research R01 grant

Personalized RL-powered Prosthetic Leg for Amputees

Official title: Towards Efficient Personalization of Computerized Lower Limb Prostheses via Reinforcement Learning in a Clinical Setup

Funded at North Carolina State University Raleigh · NIH-11375496 · Data updated 2026-11-12

A new approach uses reinforcement learning to tailor powered leg prostheses to each patient, helping people with leg amputations walk more efficiently and comfortably.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorth Carolina State University Raleigh
NIH-funded
Lab location1 site (Raleigh, United States)
Project startJuly 18, 2025
Project endJune 30, 2030
Funding year2026
Award (this year)$602,405
NIH project number5R01HD116422-02
Project IDNIH-11375496 on NIH RePORTER

Who could benefit from this research

Could help

Adults with lower-limb amputation using powered prostheses who can participate in clinical evaluation of device control personalization.

Less likely to help

Patients with non-powered prostheses or those unable to participate in RL-based tuning may not experience the proposed improvements.

What this research studies

This project aims to customize how powered lower-limb prostheses respond to individual users using reinforcement learning. By moving beyond manual, one-size-fits-all tuning, it seeks to rapidly personalize device control settings during clinical care. The goal is to improve walking efficiency, reduce compensatory strain on the back and other joints, and decrease secondary injuries for people with leg amputations. The work combines clinical data collection with intelligent adjustment of prosthesis behavior to match each user’s gait and activities.

Why it matters

Potential benefit: If successful, patients could experience more natural walking, less fatigue, and fewer pain-related issues due to better-tuned prosthetic control.

How similar studies have gone: Prior studies show RL-based personalization can adapt to individual needs in robotics, but clinical translation for powered prostheses is still developing.

Where this research is happening

  • North Carolina State University Raleigh
    Raleigh, United States
    Active

Researchers

  • Principal investigator: Huang, He — North Carolina State University Raleigh
  • Study coordinator: Huang, He

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.