NIH-funded research Career grant

Patient-Caregiver Dyadic Program to Reduce Distress for Older Adults with Cancer and Mild Cognitive Impairment

Official title: A Patient-Caregiver Behavioral Intervention for Older Adults with Cancer and Mild Cognitive Impairment

Funded at Duke University · NIH-11398081 · Data updated 2026-11-12

A five-year program to help older cancer patients with mild cognitive impairment and their family caregivers cope with distress and improve communication.

More Cognitive Impairment research and trials

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionDuke University
NIH-funded
Lab location1 site (Durham, United States)
Project startSeptember 1, 2022
Project endAugust 31, 2027
Funding year2026
Award (this year)$162,097
NIH project number5K08CA258947-05
Project IDNIH-11398081 on NIH RePORTER

Who could benefit from this research

Could help

Older adults (65+) with cancer and pre-existing mild cognitive impairment and their family caregivers who are involved in care decisions.

Less likely to help

Patients without distress or without a participating caregiver may see limited benefit.

What this research studies

This NIH K08 career development effort at Duke University will create and pilot a dyadic behavioral intervention (COPE+) designed for older adults with cancer and pre-existing mildly cognitive impairment and their informal caregivers. The project aims to reduce depression and anxiety while enhancing communication about care priorities, symptoms, and decisions within the patient-caregiver dyad. The research combines development, training, and small-scale testing to establish feasibility and guide future translational work in oncology and palliative care settings. Outcomes will focus on distress levels, patient-caregiver communication, and quality of life from the perspective of both members of the dyad.

Why it matters

Potential benefit: If successful, patients and their caregivers could experience reduced distress and better aligned care planning and communication.

How similar studies have gone: Prior individually based oncology and palliative care interventions have shown promise; this program extends the approach to a dyadic format specific to cancer with MCI.

Where this research is happening

  • Duke University
    Durham, United States
    Active

Researchers

  • Principal investigator: Ramos, Katherine — Duke University
  • Study coordinator: Ramos, Katherine

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.