Paradigm shift in managing untreated chronic lymphocytic leukemia in older adults
Official title: Paradigm Shift in the Management of Patients with Previously Untreated Chronic Lymphocytic Leukemia through NCI-sponsored Clinical Trials
Funded at Mayo Clinic Rochester · NIH-11383115 · Data updated 2026-11-12
A Mayo Clinic doctor is leading a national collaboration to advance new frontline treatments for older adults with chronic lymphocytic leukemia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 8, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $124,230 |
| NIH project number | 5R50CA291823-03 |
| Project ID | NIH-11383115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 65 and older with newly diagnosed CLL who may be eligible for front-line randomized trials.
✕Less likely to help
Patients not eligible for the specific trials or those with contraindications to the studied regimens may not benefit.
What this research studies
This grant supports the development and participation in large, multi-center clinical trials for untreated CLL in adults aged 65 and over. The effort includes finalizing and conducting existing randomized trials, analyzing outcomes and biomarkers, and preparing scholarly abstracts and manuscripts. The focus is on translating trial findings into improved first-line options for older patients, with an emphasis on collaboration through ECOG-ACRIN and Alliance clinical networks. The work will involve protocol development and acting as National Principal Investigator for upcoming front-line CLL studies. Patients and clinicians may benefit from more effective, tolerable treatment strategies as results become available.
Why it matters
Potential benefit: If successful, patients with untreated CLL could receive more effective first-line therapies tailored to older adults.
How similar studies have gone: Previous large CLL trials have shaped standard front-line therapies, supporting the potential for meaningful impact here.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Parikh, Sameer Ashok — Mayo Clinic Rochester
- Study coordinator: Parikh, Sameer Ashok
Related research
Other NIH-funded projects on the same topics.
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Tracing how chronic lymphocytic leukemia can change into Richter’s syndrome
A physician-scientist is studying why CLL sometimes changes into Richter’s syndrome and how this transition happens at the genetic level, with the goal of better outcomes for people living with CLL.
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AVO: a new triplet therapy for untreated high-risk CLL
A new, time-limited combination therapy (acalabrutinib, venetoclax, and obinutuzumab) is being tested for people with newly diagnosed high-risk CLL to see how well it works and how safe it is.
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Rewiring cancer pathways to trigger death in chronic lymphocytic leukemia
A Stanford-led study aims to use a new class of small molecules to flip cancer-driving signals so CLL cells die, offering hope for patients who have exhausted other therapies.
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METTL3's role in driving a stubborn form of chronic lymphocytic leukemia
A cancer-related study looks at how METTL3 helps a common leukemia (CLL) grow and resist treatment, with the goal of finding better therapies.
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Understanding why BTK inhibitors stop working in chronic lymphocytic leukemia
Researchers are studying why some people with chronic lymphocytic leukemia stop benefiting from BTK inhibitors and how to overcome that resistance.
-
National teamwork to improve care for chronic lymphocytic leukemia and B‑cell lymphomas
This effort brings together national cancer groups to test new targeted and combination treatments for adults with chronic lymphocytic leukemia (CLL) and other B‑cell lymphomas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.