OPTIMUM OB-TXA: Timing, route, and dose of tranexamic acid to prevent postpartum bleeding before cord clamping
Official title: OPTIMUM OB-TXA: Optimal TIMing, route and dose of tranexamic acid prior to UMbilical cord clamp for postpartum hemorrhage prevention
Funded at Inova Health Care Services · NIH-11404879 · Data updated 2026-11-12
Aims to find the best time, method, and amount of tranexamic acid given before cord clamping to prevent postpartum hemorrhage in new mothers and protect babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Inova Health Care Services NIH-funded |
| Lab location | 1 site (Fairfax, UNITED STATES) |
| Project start | August 9, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $582,131 |
| NIH project number | 5R01HD110109-05 |
| Project ID | NIH-11404879 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people undergoing delivery (vaginal or cesarean) who are at risk for postpartum hemorrhage and are eligible for TXA use.
✕Less likely to help
People delivering under conditions where TXA is not indicated or contraindicated, or who choose not to participate.
What this research studies
This project tests different ways of giving tranexamic acid to pregnant people just before the baby is born, comparing timing (when it’s given), route (intravenous or intramuscular), and dose across vaginal births, cesarean deliveries, and in people with morbid obesity. It will measure how much TXA reaches the newborn through cord blood and breast milk, and track safety and outcomes during delivery and up to 6 weeks postpartum. The research integrates maternal-fetal medicine expertise with coagulation science to identify the best approach that maximizes maternal protection while minimizing fetal and maternal risks. If successful, the study could change standard practice to prevent postpartum hemorrhage more effectively in diverse birth scenarios.
Why it matters
Potential benefit: Could significantly reduce postpartum hemorrhage risk for mothers and provide safer, clearer guidance on TXA use around delivery.
How similar studies have gone: Prior data suggest TXA can help reduce bleeding, but this exact timing, dose, and route combination around cord clamping is under investigation and may yield new insights.
Where this research is happening
-
Inova Health Care Services
Fairfax, United States Active
Researchers
- Principal investigator: Ahmadzia, Homa Khorrami — Inova Health Care Services
- Study coordinator: Ahmadzia, Homa Khorrami
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
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AI-powered real-time postpartum hemorrhage risk predictor in clinical care
A real-time AI tool integrated into electronic health records helps identify women at risk for postpartum hemorrhage so clinicians can intervene earlier.
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Targeting Ubiquitination to Improve Uterotonic Therapies in Postpartum Hemorrhage
A new approach aims to boost uterine contractions during childbirth and after delivery by understanding how a hormone receptor is regulated, potentially reducing postpartum hemorrhage risk.
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Personalized Postpartum Bleeding Risk Prediction with Machine Learning and Genetic Scores
This grant aims to create a personalized tool that predicts a mother’s risk of postpartum hemorrhage using machine learning and her genetic information.
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Simulation to strengthen obstetricians' hands-on skills for postpartum hemorrhage
A multicenter program uses realistic obstetric simulations to help OB attendings perform critical maneuvers like Bakri balloon placement and suturing techniques during postpartum hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.