Optimizing experimental design for studying genetic and environmental influences on disease using stem cells
Official title: Hierarchical modeling and simulation to optimize cell village experimental design and the analysis of scRNA-seq data
Funded at University of California Los Angeles · NIH-10996667 · Data updated 2026-11-12
This study is exploring how our genes and surroundings work together to influence diseases by using special groups of human stem cells, which helps researchers learn more about how different people might be affected in unique ways.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,308 |
| NIH project number | 1F31HG013890-01 |
| Project ID | NIH-10996667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diverse genetic backgrounds who are interested in contributing to advancements in precision medicine.
✕Less likely to help
Patients who do not have a genetic condition or are not interested in participating in experimental research may not benefit from this research.
What this research studies
This research focuses on understanding how genetic and environmental factors contribute to diseases by utilizing a novel approach called 'cell villages.' These cell villages consist of groups of genetically diverse human stem cell lines, allowing researchers to observe how variations among individuals affect molecular traits. The project aims to refine experimental methods and develop statistical tools to enhance the reliability and analysis of data generated from these cell villages, ultimately improving our understanding of gene-environment interactions in disease.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for various diseases by uncovering how genetic diversity influences health outcomes.
How similar studies have gone: Previous research has shown promise in using similar approaches to study genetic and environmental interactions, indicating potential for success in this novel application.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hanson, Chloe C — University of California Los Angeles
- Study coordinator: Hanson, Chloe C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.