Non-Invasive Venous Waveform Analysis for Heart Failure Monitoring
Official title: Non-Invasive Venous waveform Analysis (NIVA) for Monitoring Volume Status in Heart Failure Patients
Funded at Vanderbilt University Medical Center · NIH-11402683 · Data updated 2026-11-12
A new non-invasive device uses AI to monitor fluid status in people with heart failure to help guide care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2019 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $436,065 |
| NIH project number | 5R01HL148244-08 |
| Project ID | NIH-11402683 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with heart failure, including those with tricuspid regurgitation, heart transplantation, or LVAD support, who can undergo venous waveform measurements.
✕Less likely to help
Patients without heart failure or those unable to participate in non-invasive monitoring may not benefit.
What this research studies
This project refines an AI-powered NIVAHF device that reads venous waveforms to estimate heart-failure–related volume status. It builds on prior work to improve accuracy, especially in patients with tricuspid regurgitation, heart transplants, or LVAD support. The study aims to optimize the AI algorithm, reduce errors, and validate the NIVA score as a surrogate for traditional hemodynamic measurements. Participants would contribute data from venous waveform measurements to help tailor treatment decisions.
Why it matters
Potential benefit: If successful, patients with heart failure could receive more precise, non-invasive monitoring to guide treatment and prevent complications.
How similar studies have gone: Previous NIVAHF research showed promise in non-invasively estimating pressure-related status using AI, with ongoing optimization.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Alvis, Bret D. — Vanderbilt University Medical Center
- Study coordinator: Alvis, Bret D.
Related research
Other NIH-funded projects on the same topics.
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Non-invasive venous waveform monitor for fluid status in heart failure patients
This project uses a small sensor and AI to estimate vein pressure so people with heart failure can get easier, non-invasive monitoring of their fluid status.
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Lowering heart failure risk for people with diabetes and low income
This project brings problem-solving training, community health workers, and local support to people with diabetes, obesity, and low income who have early heart changes to help improve fitness, control risk factors, and feel better.
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Monitoring fluid levels in heart failure patients using a non-invasive device
This study is working on a special device that helps monitor fluid levels in people with heart failure, especially those with certain heart conditions or who have had heart transplants, to make sure they get the best care possible.
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Exploring how low socioeconomic status and diabetes affect heart failure risk
This study is looking at how being low-income and having diabetes can affect your heart health, especially for people from different racial and ethnic backgrounds, and it will involve 350 participants trying out helpful programs to improve their health and lifestyle.
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Impact of the DASH diet on heart failure in older adults
This study is looking at how a special diet called the DASH diet can help improve heart health in older adults over 65 with heart failure, by providing them with meals delivered to their homes and checking how it affects their health.
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AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.