Non-inferiority comparison of live vs. self-guided remote lifestyle programs
Official title: A non-inferiority trial comparing synchronous and asynchronous remotely-delivered lifestyle interventions
Funded at University of Connecticut Storrs · NIH-11394474 · Data updated 2026-11-12
A study tests whether two remotely-delivered lifestyle programs (one with real-time coaching and one that participants lead themselves) produce similar weight loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $403,250 |
| NIH project number | 5R01DK136795-04 |
| Project ID | NIH-11394474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults interested in weight management who are willing to participate in either synchronous or asynchronous remote programs.
✕Less likely to help
Individuals who cannot use online platforms or do not engage with remote coaching may receive little benefit.
What this research studies
This project compares two online lifestyle programs delivered remotely to adults seeking weight management. One intervention uses synchronous coaching via video or phone, while the other is asynchronous and allows 24/7 online interaction where participants and clinicians exchange messages and support. The researchers look at weight loss, engagement, and how sustainable the program is after the active period ends, including a year of self-led group activity. The study builds on prior work suggesting remote coaching can be scalable and effective, and asks if a self-led approach can match outcomes with ongoing peer support. Results could inform scalable, low-cost options for weight management in real-world settings.
Why it matters
Potential benefit: If successful, patients could access effective, scalable weight management programs remotely with less need for real-time clinician time.
How similar studies have gone: Previous studies show similar weight loss and acceptability between different remote formats, with potential for sustainability in group-led formats.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Pagoto, Sherry L. — University of Connecticut Storrs
- Study coordinator: Pagoto, Sherry L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.