How IL-10 changes mast cells in allergic reactions
Official title: Differential regulation of mast cell-mediated allergic responses by IL-10
Funded at University of Connecticut Storrs · NIH-11467503 · Data updated 2026-11-12
This work looks at how the immune signal IL-10 changes mast cells and their responses in people with food allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $77,713 |
| NIH project number | 3R01AI167884-04S1 |
| Project ID | NIH-11467503 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with diagnosed food allergies, recurrent allergic inflammation, or a history of anaphylaxis would be the most relevant candidates to contribute samples or join future related trials.
✕Less likely to help
Patients whose allergies are not driven by mast cells or IL-10-regulated pathways, or those without food-related allergic disease, may not benefit directly.
What this research studies
Researchers will examine how the immune molecule IL-10 influences mast cell number, types, and activation during food allergy. They will use lab experiments on mast cells, cell-based tests, and animal models of both IgE and non-IgE food allergic responses to compare reactions to different allergens and IL-10 sources. The team will profile distinct mast cell subsets and map the signaling steps that drive cell growth and release of allergy-causing substances. Findings are intended to reveal mechanisms that could guide future patient-directed treatments.
Why it matters
Potential benefit: If successful, this work could identify new targets to prevent or lessen severe food-allergic reactions by modifying IL-10 effects on mast cells.
How similar studies have gone: Prior studies have shown IL-10 can both enhance and suppress mast cell function, but applying these findings to specific mast cell lineages in food allergy is relatively new.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Mathias, Clinton B — University of Connecticut Storrs
- Study coordinator: Mathias, Clinton B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.