New tools to visualize gene activity in the human brain
Next generation spatial genomics tools for the human brain
This study is working on improving a special technology that helps scientists see how genes are expressed in brain tissues, which is important for understanding brain disorders, and it's designed for researchers who want to learn more about these conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spatial Genomics, INC. NIH-funded |
| Lab location | 1 site (Pasadena, UNITED STATES) |
| Project ID | NIH-11186828 on NIH RePORTER |
What this research studies
This research focuses on advancing spatial genomics technology to better visualize gene expression in human brain tissues, which is crucial for understanding neurological disorders. The team at Spatial Genomics is working on enhancing their Gene Positioning System (GenePS) platform, which utilizes a method called sequential fluorescence in situ hybridization (seqFISH) to image thousands of genes directly in brain samples. By developing new assays that can be reliably used across various brain tissues, this project aims to overcome current limitations such as high autofluorescence and poor RNA quality in brain samples.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or conditions that affect brain function.
Not a fit: Patients with non-neurological conditions or those not affected by brain-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of neurological disorders by providing detailed insights into gene interactions in the brain.
How similar studies have performed: Previous research has shown promise in using spatial genomics for other tissues, suggesting potential success for similar approaches in brain tissues.
Where this research is happening
Pasadena, UNITED STATES
- Spatial Genomics, INC. — Pasadena, United States (Active)
Researchers
- Principal investigator: Frieda, Kirsten — Spatial Genomics, INC.
- Study coordinator: Frieda, Kirsten
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.