Analyzing gene expression in the brains of Alzheimer's patients
Spatial single cell analysis of the human Alzheimer's Disease brain
This study is looking at the brains of people with Alzheimer's to better understand how their cells work and interact, using special technology to see thousands of genes at once, which could help us find new ways to understand and treat the disease.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spatial Genomics, INC. NIH-funded |
| Lab location | 1 site (Pasadena, UNITED STATES) |
| Project ID | NIH-10932284 on NIH RePORTER |
What this research studies
This research focuses on examining the brains of individuals with Alzheimer's Disease using advanced technology to analyze gene expression at the single-cell level. By employing a method called sequential fluorescence in situ hybridization (seqFISH), researchers will be able to visualize thousands of genes in brain samples, helping to identify changes in cell types and their interactions. This approach aims to enhance our understanding of the cellular mechanisms involved in Alzheimer's, potentially leading to new insights into the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those exhibiting symptoms of cognitive decline.
Not a fit: Patients without a diagnosis of Alzheimer's Disease or related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding Alzheimer's Disease, paving the way for more effective treatments.
How similar studies have performed: Previous research using similar single-cell analysis techniques has shown promise in understanding complex diseases, suggesting potential for success in this novel application.
Where this research is happening
Pasadena, UNITED STATES
- Spatial Genomics, INC. — Pasadena, United States (Active)
Researchers
- Principal investigator: Frieda, Kirsten — Spatial Genomics, INC.
- Study coordinator: Frieda, Kirsten
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.