Analyzing gene expression in the brains of Alzheimer's patients
Official title: Spatial single cell analysis of the human Alzheimer's Disease brain
Funded at Spatial Genomics, INC. · NIH-10932284 · Data updated 2026-11-12
This study is looking at the brains of people with Alzheimer's to better understand how their cells work and interact, using special technology to see thousands of genes at once, which could help us find new ways to understand and treat the disease.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spatial Genomics, INC. NIH-funded |
| Lab location | 1 site (Pasadena, UNITED STATES) |
| Project start | September 21, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,229,313 |
| NIH project number | 5R44AG085832-02 |
| Project ID | NIH-10932284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those exhibiting symptoms of cognitive decline.
✕Less likely to help
Patients without a diagnosis of Alzheimer's Disease or related cognitive impairments may not benefit from this research.
What this research studies
This research focuses on examining the brains of individuals with Alzheimer's Disease using advanced technology to analyze gene expression at the single-cell level. By employing a method called sequential fluorescence in situ hybridization (seqFISH), researchers will be able to visualize thousands of genes in brain samples, helping to identify changes in cell types and their interactions. This approach aims to enhance our understanding of the cellular mechanisms involved in Alzheimer's, potentially leading to new insights into the disease.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding Alzheimer's Disease, paving the way for more effective treatments.
How similar studies have gone: Previous research using similar single-cell analysis techniques has shown promise in understanding complex diseases, suggesting potential for success in this novel application.
Where this research is happening
-
Spatial Genomics, INC.
Pasadena, United States Active
Researchers
- Principal investigator: Frieda, Kirsten — Spatial Genomics, INC.
- Study coordinator: Frieda, Kirsten
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.