New technology for imaging brain activity in real-time
Official title: System for Volumetric 2-photon Imaging of Neuroactivity Using Light Beads Microscopy
Funded at Microbrightfield, LLC · NIH-10897999 · Data updated 2026-11-12
This study is testing a new type of microscope that helps scientists see how brain cells in mice work together, which could lead to better treatments for brain disorders that affect people like you.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microbrightfield, LLC NIH-funded |
| Lab location | 1 site (Williston, United States) |
| Project start | September 5, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $996,633 |
| NIH project number | 5R44MH132234-03 |
| Project ID | NIH-10897999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with neurological conditions or brain disorders, as well as those interested in the underlying mechanisms of brain function.
✕Less likely to help
Patients with conditions unrelated to brain function or those not involved in neurological research may not receive direct benefits from this research.
What this research studies
This research focuses on developing a groundbreaking microscope called the Volumetric Calcium Imaging 2-Photon Activity Microscope (vCAm™) that utilizes Light Beads Microscopy to capture the activity of individual neurons in the mouse brain. By enabling high-resolution imaging across multiple layers of the cerebral cortex, this technology allows researchers to observe how neurons interact during various behavioral states. The approach aims to provide insights into the complex dynamics of brain activity, which could lead to better understanding of brain disorders. Patients may benefit indirectly through advancements in neuroscience that could inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding and treating brain diseases and disorders.
How similar studies have gone: While the approach is innovative, similar imaging technologies have shown promise in neuroscience, suggesting potential for success in this novel application.
Where this research is happening
-
Microbrightfield, LLC
Williston, United States Active
Researchers
- Principal investigator: Glaser, Jacob R — Microbrightfield, LLC
- Study coordinator: Glaser, Jacob R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.