A new method for analyzing RNA and protein distribution in brain tissue.
Official title: NeuroExM
Funded at Microbrightfield, LLC · NIH-10906114 · Data updated 2026-11-12
This study is testing a new way to look at brain tissue more clearly, which could help us understand brain diseases better and improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microbrightfield, LLC NIH-funded |
| Lab location | 1 site (Williston, United States) |
| Project start | July 2, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $994,696 |
| NIH project number | 5R42MH124566-04 |
| Project ID | NIH-10906114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions or diseases that affect brain function.
✕Less likely to help
Patients with conditions unrelated to brain function or those who do not have access to the required tissue samples may not benefit from this research.
What this research studies
This research focuses on developing NeuroExM™, a cutting-edge technique that enhances the ability to visualize and analyze the spatial distribution of messenger RNAs and proteins in brain tissue. By using expansion microscopy, the tissue is expanded to allow for high-resolution imaging of small biological structures that are typically difficult to see. This method enables repeated imaging and analysis of the same tissue samples, providing detailed insights into neuronal structures and their functions. Patients may benefit from advancements in understanding brain diseases and disorders through this innovative approach.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of brain diseases by providing detailed insights into cellular processes.
How similar studies have gone: Other research has shown success with similar expansion microscopy techniques, indicating a promising avenue for further exploration.
Where this research is happening
-
Microbrightfield, LLC
Williston, United States Active
Researchers
- Principal investigator: Glaser, Jacob R — Microbrightfield, LLC
- Study coordinator: Glaser, Jacob R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.