A new microscope for imaging brain activity
Official title: Microscope system for large scale optical imaging of neuronal activity using kilohertz frame rates
Funded at Microbrightfield, LLC · NIH-11003971 · Data updated 2026-11-12
This study is testing a new type of microscope that helps scientists see how brain cells talk to each other in real-time, which could help us understand brain function better and find new ways to treat brain disorders.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microbrightfield, LLC NIH-funded |
| Lab location | 1 site (Williston, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $995,876 |
| NIH project number | 5R44MH129023-04 |
| Project ID | NIH-11003971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders or conditions affecting brain function, as they may benefit from the insights gained through this advanced imaging technology.
✕Less likely to help
Patients with non-neurological conditions or those not affected by brain disorders may not receive direct benefits from this research.
What this research studies
This research focuses on developing the 2P-ActivityScope™, an advanced microscope that utilizes a novel technology called SLAP2 to capture high-resolution images of neuronal activity in real-time. By employing fluorescent indicators, this microscope can visualize how neurons communicate and process information at an unprecedented speed and detail. This technology aims to enhance our understanding of brain function and could lead to breakthroughs in treating brain disorders. The research involves both in vivo and in vitro imaging techniques to study neuronal behavior.
Why it matters
Potential benefit: If successful, this research could significantly advance our understanding of brain function and lead to improved treatments for various neurological conditions.
How similar studies have gone: Other research has shown success with advanced imaging technologies in neuroscience, but the specific approach of the 2P-ActivityScope is novel and untested in a commercial context.
Where this research is happening
-
Microbrightfield, LLC
Williston, United States Active
Researchers
- Principal investigator: Glaser, Jacob R — Microbrightfield, LLC
- Study coordinator: Glaser, Jacob R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.