Automated analysis of axonal fibers in the brain using advanced software
Official title: Next generation axonal quantification and classification using AI
Funded at Microbrightfield, LLC · NIH-10868467 · Data updated 2026-11-12
This study is testing a new software called HyperAxon™ that helps scientists look at brain tissue more closely by automatically mapping the tiny nerve fibers, which could help us understand brain connections and changes in conditions like neurological disorders.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microbrightfield, LLC NIH-funded |
| Lab location | 1 site (Williston, United States) |
| Project start | August 19, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $850,421 |
| NIH project number | 5R44MH128076-03 |
| Project ID | NIH-10868467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neuropsychiatric or neurological disorders who may benefit from enhanced diagnostic tools.
✕Less likely to help
Patients with conditions unrelated to axonal injury or those not requiring advanced imaging techniques may not benefit from this research.
What this research studies
This research focuses on developing HyperAxon™, a cutting-edge software designed to automatically analyze axonal fibers in brain tissue. By utilizing advanced deep learning techniques, the software can accurately segment, trace, and reconstruct axonal fibers in both 2D and 3D microscopy images, even in areas with high fiber density. This innovative approach aims to provide researchers with deeper insights into neural connectivity and the changes associated with neurological disorders. The software will be tested on both animal models and human post-mortem tissue to validate its effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and diagnosis of neuropsychiatric and neurological disorders.
How similar studies have gone: Other research has shown promise in using advanced imaging and AI techniques for analyzing neural structures, indicating potential success for this novel approach.
Where this research is happening
-
Microbrightfield, LLC
Williston, United States Active
Researchers
- Principal investigator: Glaser, Jacob R — Microbrightfield, LLC
- Study coordinator: Glaser, Jacob R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.