New immune-target ideas for autoimmune endocrine diseases
Official title: Identifying new immunotherapeutic targets for endocrine autoimmunity.
Funded at University of California Los Angeles · NIH-11591245 · Data updated 2026-11-12
Doctors are exploring immune-based ideas to treat autoimmune diseases that affect hormone-producing glands.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $250,000 |
| NIH project number | 3U19AI181729-03S1 |
| Project ID | NIH-11591245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with autoimmune endocrine diseases or those who have immune-related adverse events from cancer immunotherapy may benefit from future therapies developed through this work.
✕Less likely to help
This grant does not involve direct patient treatment now; benefits would come from future therapies that arise from this research.
What this research studies
This grant aims to uncover how the immune system causes lasting damage in autoimmune endocrine conditions and to identify new targets for immunotherapies. It looks at epigenetic and gene activity changes that keep the immune attack going, and at how certain immune cells may shift from resting to attacking states. It also studies how cancer treatment–related immune side effects occur, since these share immune pathways with endocrinopathies. A pilot project will consider differences between sexes, since these conditions often affect men and women differently. The work combines lab studies with analysis of patient data to map where and when immune processes go wrong.
Why it matters
Potential benefit: If successful, people with autoimmune endocrine diseases could have new, targeted immunotherapies that reduce damage to hormone-producing tissues.
How similar studies have gone: Previous research in autoimmunity has identified immune pathways, and new targets here may build on that groundwork with a focus on endocrine tissues.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Su, Maureen a — University of California Los Angeles
- Study coordinator: Su, Maureen a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.