NIH-funded research R01 grant

New daily loneliness indicators and aging outcomes

Official title: Novel Indicators of Day-to-Day Loneliness and Aging: Examining Biological, Phenotypic, and Functional Outcomes Across Multiple Timescales

Funded at Arizona State University-Tempe Campus · NIH-11434934 · Data updated 2026-11-12

Researchers are studying how day-to-day loneliness affects aging and health in adults, to uncover how loneliness might speed up biological aging and functional decline.

More Loneliness research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionArizona State University-Tempe Campus
NIH-funded
Lab location1 site (Scottsdale, United States)
Project startSeptember 1, 2026
Project endMay 31, 2031
Funding year2026
Award (this year)$677,756
NIH project number1R01AG104067-01
Project IDNIH-11434934 on NIH RePORTER

Who could benefit from this research

Could help

Adults 21 years and older who participate in or are part of ongoing aging studies or cohorts and who experience daily loneliness.

Less likely to help

Individuals not experiencing loneliness or not enrolled in aging cohorts may see limited direct benefit.

What this research studies

This project looks at how daily changes in loneliness relate to aging over time, using data from two long-term studies of adults. It examines three patterns—average loneliness, day-to-day fluctuations, and responses to daily events—and how these relate to biological, physical, and cognitive aging. By following participants over several years, the team aims to connect everyday feelings of loneliness with long-term health outcomes and to see whether behaviors like smoking or poor sleep worsen these effects. The study leverages existing cohorts to explore mechanisms and potential intervention points to improve aging health.

Why it matters

Potential benefit: If successful, this work could inform interventions to reduce loneliness-related aging risks and improve longevity and healthspan for adults.

How similar studies have gone: Prior work suggests daily loneliness patterns relate to health outcomes, though this project expands to multiple aging pathways and long-term effects.

Where this research is happening

  • Arizona State University-Tempe Campus
    Scottsdale, United States
    Active

Researchers

  • Principal investigator: Koffer, Rachel E — Arizona State University-Tempe Campus
  • Study coordinator: Koffer, Rachel E

Related research

Other NIH-funded projects on the same topics.

  • How loneliness affects brain aging and Alzheimer's disease risk

    This study is looking at how feeling lonely might affect the brains of older adults who are at risk for Alzheimer's disease, hoping to find clues that could help us understand and predict changes in brain health.

    NIH research Mcgill University · Montreal, Canada · NIH-11081953

  • Understanding loneliness in older adults with schizophrenia

    This study is looking at how feeling lonely affects older adults with schizophrenia and their overall health and happiness, and it includes both those with schizophrenia and others their age without mental health issues to see how their experiences compare.

    NIH research University of California, San Diego · La Jolla, United States · NIH-10868738

  • How loneliness affects brain aging and Alzheimer's disease risk

    This study is looking at how feeling lonely might affect brain health as we age, especially for older adults who are at risk for Alzheimer's, to help us understand if loneliness can lead to changes in the brain and speed up memory problems.

    NIH research Mcgill University · Montreal, Canada · NIH-10836473

  • How loneliness and social isolation affect brain aging and Alzheimer's disease

    This study is looking at how feeling lonely and being socially isolated can affect memory and thinking as we age, especially in older adults, and it aims to find ways to help people connect with others to improve their overall well-being and reduce the risk of Alzheimer's disease.

    NIH research University of Rochester · Rochester, United States · NIH-10784034

  • Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)

    A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.

    NIH research Yale University · New Haven, United States · NIH-11638490

  • Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory

    This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.

    NIH research University of Chicago · Chicago, United States · NIH-11623260

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.