Neutrophil-monocyte communication to improve heart healing after a heart attack
Official title: A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injury
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11380758 · Data updated 2026-11-12
A patient-centered look at how white blood cells talk to each other after a heart attack to help the heart heal better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $557,857 |
| NIH project number | 5R01HL156856-06 |
| Project ID | NIH-11380758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have had a recent myocardial infarction and are at risk for complications from inflammation.
✕Less likely to help
Patients without heart inflammation or those not undergoing post-heart attack care may not benefit from these findings.
What this research studies
After a heart attack, the body’s inflammation helps clear debris but can also cause extra harm if it goes unchecked. This grant studies how neutrophils and monocytes interact in the damaged heart to control inflammation and promote repair. Researchers use human-relevant heart cell findings and immune signaling to identify points where therapy could support healing without suppressing needed protection. The goal is to understand the timing and signals that shift inflammation from harmful to helpful, potentially guiding new treatments.
Why it matters
Potential benefit: If successful, the work could lead to treatments that improve heart healing and reduce heart failure risk after a heart attack.
How similar studies have gone: Previous work shows neutrophil-driven inflammation is linked to outcomes after a heart attack, with potential for translation to new therapies.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Nagareddy, Prabhakara Reddy — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Nagareddy, Prabhakara Reddy
Related research
Other NIH-funded projects on the same topics.
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-
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This project aims to find better ways to understand and treat heart muscle injury that can happen when someone has sepsis.
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How neutrophils and monocytes coordinate to help the heart heal after a heart attack
The team is learning how early immune cells (neutrophils and monocytes) clear damage and calm inflammation after a heart attack to improve healing.
-
Investigating a new method for early detection of heart tissue damage
This study is testing a new imaging method using a special tracer to spot early signs of heart scarring, which can help doctors catch heart problems sooner and improve treatment options for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.