Investigating a new method for early detection of heart tissue damage
Mechanism of F-18-fluorodeoxyglucarate accrual in myocardial injury
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-11063262
This study is testing a new imaging method using a special tracer to spot early signs of heart scarring, which can help doctors catch heart problems sooner and improve treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11063262 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel imaging technique using a radiotracer called 18F-fluoroglucaric acid (18F-FGA) to detect early signs of cardiac fibrosis, a condition that can lead to heart failure. By utilizing positron emission tomography (PET), which offers high resolution and sensitivity, the study aims to identify fibrosis before it becomes irreversible. Current methods for diagnosing cardiac fibrosis are either invasive or lack sensitivity, making this new approach potentially transformative for early intervention in heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced heart conditions such as myocardial infarction or myocarditis and are at risk of developing cardiac fibrosis.
Not a fit: Patients with stable heart conditions who do not exhibit signs of fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of heart tissue damage, allowing for timely treatment and potentially reversing fibrosis.
How similar studies have performed: Previous research has shown promising results with similar imaging techniques, indicating potential for success in this novel approach.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AWASTHI, VIBHUDUTTA — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: AWASTHI, VIBHUDUTTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: amyloid disease