Neuroimaging and multi-omics to subtype Alzheimer's and predict its course with confidence
Official title: Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease
Funded at Wake Forest University · NIH-11445042 · Data updated 2026-11-12
A project at Wake Forest University aims to combine brain scans with genetic, RNA, and protein data to identify distinct Alzheimer's subtypes and predict how the disease will progress with reliable uncertainty estimates.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $526,607 |
| NIH project number | 1R15AG103945-01 |
| Project ID | NIH-11445042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with Alzheimer’s disease or related dementias who have access to advanced neuroimaging and omics data.
✕Less likely to help
Patients without access to the necessary imaging or omics data or those not enrolled in brain-imaging studies may not benefit.
What this research studies
This research will fuse neuroimaging data with multi-omics information to reveal molecular-brain patterns associated with different Alzheimer’s subtypes. It uses graph-based methods to map interactions across imaging and omics layers and to discover interpretable groups of patients. The team will develop deep learning models that forecast cognitive and neurodegenerative trajectories while providing calibrated confidence in those predictions. The goal is to improve clinical decision-making by offering more personalized prognosis rather than a single overall trajectory.
Why it matters
Potential benefit: If successful, patients and clinicians could receive more accurate subtype information and personalized progression forecasts to guide treatment and planning.
How similar studies have gone: Preliminary work in neuroimaging genetics has linked brain structure to genetics, but integrating multi-omics with predictive confidence is still emerging.
Where this research is happening
-
Wake Forest University
Winston-Salem, United States Active
Researchers
- Principal investigator: Chen, Minghan — Wake Forest University
- Study coordinator: Chen, Minghan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.