NIH-funded research R01 grant

Navigation-based care pathway to speed adjuvant therapy for head and neck cancer

Official title: A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck Cancer

Funded at Medical University of South Carolina · NIH-11387560 · Data updated 2026-11-12

A practical program tests a navigation-driven approach to help patients with head and neck cancer start postoperative radiation on time, aiming to improve survival.

More Head and Neck Cancer research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMedical University of South Carolina
NIH-funded
Lab location1 site (Charleston, United States)
Project startAugust 1, 2023
Project endJuly 31, 2028
Funding year2026
Award (this year)$690,975
NIH project number5R01CA282165-04
Project IDNIH-11387560 on NIH RePORTER

Who could benefit from this research

Could help

Adults with head and neck cancer who have undergone surgery and are candidates for postoperative radiation therapy.

Less likely to help

Patients who are not receiving postoperative radiation therapy or whose treatment plans do not involve the proposed PORT timeline.

What this research studies

This project tests a navigation-based, multilevel intervention designed to streamline care after surgery for head and neck cancer. It looks at how patient, team, and hospital factors affect whether postoperative radiation therapy starts within the recommended 6 weeks, and whether a coordinated navigation program can shorten delays. The study uses a stepped-wedge cluster design across four cancer centers to measure both outcomes and how the program is put into practice in real clinics. Prior pilot work suggested the approach is feasible and acceptable, and this trial will build on that to confirm effectiveness and identify key implementation factors.

Why it matters

Potential benefit: If successful, patients could start needed adjuvant radiation therapy sooner, potentially improving survival.

How similar studies have gone: Preliminary data from pilot work showed feasibility and potential effectiveness of the navigation approach in improving timely PORT.

Where this research is happening

  • Medical University of South Carolina
    Charleston, United States
    Active

Researchers

  • Principal investigator: Graboyes, Evan Michael — Medical University of South Carolina
  • Study coordinator: Graboyes, Evan Michael

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.