Navigation-based care pathway to speed adjuvant therapy for head and neck cancer
Official title: A Type I Hybrid Effectiveness-Implementation Trial to Evaluate a Navigation-Based Multilevel Intervention to Decrease Delays Starting Adjuvant Therapy Among Patients with Head and Neck Cancer
Funded at Medical University of South Carolina · NIH-11387560 · Data updated 2026-11-12
A practical program tests a navigation-driven approach to help patients with head and neck cancer start postoperative radiation on time, aiming to improve survival.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $690,975 |
| NIH project number | 5R01CA282165-04 |
| Project ID | NIH-11387560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with head and neck cancer who have undergone surgery and are candidates for postoperative radiation therapy.
✕Less likely to help
Patients who are not receiving postoperative radiation therapy or whose treatment plans do not involve the proposed PORT timeline.
What this research studies
This project tests a navigation-based, multilevel intervention designed to streamline care after surgery for head and neck cancer. It looks at how patient, team, and hospital factors affect whether postoperative radiation therapy starts within the recommended 6 weeks, and whether a coordinated navigation program can shorten delays. The study uses a stepped-wedge cluster design across four cancer centers to measure both outcomes and how the program is put into practice in real clinics. Prior pilot work suggested the approach is feasible and acceptable, and this trial will build on that to confirm effectiveness and identify key implementation factors.
Why it matters
Potential benefit: If successful, patients could start needed adjuvant radiation therapy sooner, potentially improving survival.
How similar studies have gone: Preliminary data from pilot work showed feasibility and potential effectiveness of the navigation approach in improving timely PORT.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Graboyes, Evan Michael — Medical University of South Carolina
- Study coordinator: Graboyes, Evan Michael
Related research
Other NIH-funded projects on the same topics.
-
Helping people with head and neck cancer start post-surgery radiation on time
This project uses a patient navigation program to help people with head and neck cancer begin their recommended post-surgery radiation within six weeks of surgery.
-
Improving timely cancer treatment for head and neck cancer patients
This study is testing a helpful program that guides patients with head and neck cancer to make sure they get their radiation therapy on time, especially for those who might not have easy access to care.
-
Combined Imaging and RNA Markers to Predict Head and Neck Cancer Recurrence
A research project aims to use imaging and RNA data to better predict if head and neck cancer will come back, helping doctors tailor treatments for patients.
-
Biomarker to guide treatment in head and neck cancer
A biomarker test using tumor samples is being developed to predict recurrence risk in oral cancers and help tailor treatment.
-
Intensive dental care during cancer follow-up to protect teeth after head and neck radiation
A program delivered in oncology clinics to provide fluoride varnish and dental follow-up aims to reduce tooth decay and improve oral health and quality of life for head and neck cancer patients after radiation therapy.
-
AI-powered radiotherapy planning for cervical and head-and-neck cancer
A computer program helps plan radiation therapy for cervical and head-and-neck cancer patients to make treatments faster and more accurate.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.