Mouse Phenotyping Informatics Infrastructure for linking genes to diseases
Official title: Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.
Funded at European Molecular Biology Laboratory · NIH-11401882 · Data updated 2026-11-12
A big data project to map mouse gene changes to disease traits by collecting and analyzing thousands of mouse phenotypes to help understand human cardiac diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | European Molecular Biology Laboratory NIH-funded |
| Lab location | 1 site (Heidelberg, Germany) |
| Project start | September 16, 2011 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $814,213 |
| NIH project number | 5UM1HG006370-15 |
| Project ID | NIH-11401882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cardiac diseases or those contributing genetic samples might indirectly benefit through improved disease models and future therapies.
✕Less likely to help
This grant does not involve direct patient participation or clinical interventions today.
What this research studies
This project builds and improves a data-friendly platform that collects high-throughput mouse phenotype information, analyzes it, and links findings to human disease data. Researchers will generate and quality-check hundreds of thousands of images and phenotypes, then integrate them with genomic and human disease information to identify potential disease models. The work aims to provide researchers with standardized methods and FAIR data so patients’ conditions, including cardiac disorders, can be studied more effectively in the future. The effort is led by the European Molecular Biology Laboratory and collaborates across groups to translate mouse findings toward human health insights.
Why it matters
Potential benefit: If successful, this work could accelerate discovery of mouse models for human cardiac diseases and speed translation of genetic findings into therapeutic insights.
How similar studies have gone: Previous mouse phenotyping initiatives have generated valuable disease models and linked genes to human conditions, with ongoing expansion and integration improving translational potential.
Where this research is happening
-
European Molecular Biology Laboratory
Heidelberg, Germany Active
Researchers
- Principal investigator: Parkinson, Helen Elizabeth — European Molecular Biology Laboratory
- Study coordinator: Parkinson, Helen Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.