Mouse genetics platform linking mouse traits to human heart disease
Official title: Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.
Funded at European Molecular Biology Laboratory · NIH-11135328 · Data updated 2026-11-12
This project builds a shared mouse-data platform to find mouse strains and gene links that could help people with heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | European Molecular Biology Laboratory NIH-funded |
| Lab location | 1 site (Heidelberg, Germany) |
| Project start | September 16, 2011 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $743,148 |
| NIH project number | 5UM1HG006370-14 |
| Project ID | NIH-11135328 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cardiac disorders who are interested in contributing health data or biospecimens or who want to be considered for future trials informed by genetic discoveries would be most relevant to this effort.
✕Less likely to help
People seeking immediate clinical care or direct treatment from this project are unlikely to receive immediate personal benefit.
What this research studies
From a patient's perspective, researchers collect detailed trait data and images from many mouse strains, standardize those tests, and run automated analysis and quality checks so results are reliable. They use large-scale image analysis (over 500,000 images) and improved statistical pipelines to discover gene-phenotype links that may model human cardiac disease. The data are curated to FAIR standards and shared across a global consortium so clinicians and scientists can quickly access candidate mouse models. The platform also maps mouse findings to human clinical descriptions to help identify strains relevant to specific heart conditions.
Why it matters
Potential benefit: If successful, this work could speed the discovery of mouse models and gene-disease links that enable new diagnostics, treatments, and clinical trials for heart conditions.
How similar studies have gone: Previous international mouse phenotyping consortia have produced many useful gene-phenotype links and widely used mouse strains, so this approach builds on proven, productive work.
Where this research is happening
-
European Molecular Biology Laboratory
Heidelberg, Germany Active
Researchers
- Principal investigator: Parkinson, Helen Elizabeth — European Molecular Biology Laboratory
- Study coordinator: Parkinson, Helen Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.