Strengthening genetic association data and polygenic score resources for health
Official title: Strengthening community knowledge bases for genetic association studies and polygenic scores, the GWAS and PGS Catalogs
Funded at European Molecular Biology Laboratory · NIH-11421439 · Data updated 2026-11-12
A big NIH project to improve and expand public catalogs of genetic associations and polygenic scores so researchers and clinicians can better understand complex diseases like cancer, heart disease, and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | European Molecular Biology Laboratory NIH-funded |
| Lab location | 1 site (Heidelberg, Germany) |
| Project start | September 20, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $677,079 |
| NIH project number | 5U24HG012542-05 |
| Project ID | NIH-11421439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians using genetic association data and polygenic scores to study cancers, cardiovascular diseases, and diabetes.
✕Less likely to help
The project itself does not directly enroll patients or provide immediate treatments.
What this research studies
This grant funds the European Molecular Biology Laboratory to keep the GWAS Catalog up-to-date with high-quality, interoperable data. It focuses on automating data curation, improving search and visualization, and linking GWAS data with Polygenic Score resources to support researchers and clinicians. The work emphasizes FAIR data principles to make data easily findable and reusable while respecting ethical constraints. By integrating GWAS with PGS and related resources, it aims to streamline analyses that could inform patient care in complex diseases.
Why it matters
Potential benefit: If successful, patients could benefit from more reliable genetic knowledge that informs risk prediction and personalized approaches to prevention and treatment.
How similar studies have gone: Past GWAS and PGS catalogs have proven valuable for enabling large-scale genetic insights and replication.
Where this research is happening
-
European Molecular Biology Laboratory
Heidelberg, Germany Active
Researchers
- Principal investigator: Parkinson, Helen Elizabeth — European Molecular Biology Laboratory
- Study coordinator: Parkinson, Helen Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.