Monitoring how immune cells function in patients after stem cell transplants
In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant
This study is looking at how well the immune system works in patients who have had stem cell transplants, especially focusing on a type of white blood cell called neutrophils that help fight infections, to find better ways to predict and prevent serious fungal infections after their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11011430 on NIH RePORTER |
What this research studies
This research investigates the immune response of patients who have undergone hematopoietic stem cell transplants, particularly focusing on neutrophils, a type of white blood cell crucial for fighting infections. The study aims to develop new biomarkers that can more accurately predict the risk of invasive fungal infections in these patients, as traditional measures of neutrophil recovery are often insufficient. By examining the communication and coordination of neutrophils, known as swarming, the research seeks to understand how this function changes over time after the transplant. This could lead to improved management strategies for preventing infections in vulnerable patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have recently undergone hematopoietic stem cell transplants and are at risk for fungal infections.
Not a fit: Patients who have not undergone stem cell transplants or those with conditions unrelated to fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better tools for predicting and preventing serious fungal infections in patients recovering from stem cell transplants.
How similar studies have performed: Other research has shown promise in developing biomarkers for immune response, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Irimia, Daniel — Massachusetts General Hospital
- Study coordinator: Irimia, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.