Molecular protections against oxidation in Parkinson’s disease and Lewy body dementia
Official title: Molecular Mechanisms of Oxidation Resistance 1 in Parkinson's disease and Lewy Body Dementia
Funded at Medical University of South Carolina · NIH-11336842 · Data updated 2026-11-12
A study to understand how Oxr1 helps neurons resist damage in Parkinson’s disease and Lewy body dementia, with potential to guide new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $598,264 |
| NIH project number | 5R01NS133688-04 |
| Project ID | NIH-11336842 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is conducted in laboratory models and analyses; future patient participation could come through translational studies or clinical trials if findings advance.
✕Less likely to help
Participants in future trials may not experience direct benefit during early-stage investigations, as this study is foundational.
What this research studies
Parkinson’s disease and Lewy body dementia involve neuron loss and harmful protein clumps. This project looks at Oxr1, a protein that helps cells cope with oxidative stress and other damaging processes in brain cells. By studying how Oxr1 works in preclinical models, researchers hope to uncover mechanisms that protect neurons and reduce disease-related damage. The goal is to translate this knowledge into strategies that could slow progression or improve brain health in patients. The work is focused on the neurobiology of human-relevant disease processes using laboratory models and biological analysis.
Why it matters
Potential benefit: If successful, the research could inform new therapeutic approaches that strengthen neuronal defenses against oxidative damage in PD and DLB.
How similar studies have gone: Previous work shows Oxr1-related pathways can influence neuroprotection in PD models, supporting potential translational relevance.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Thomas, Bobby — Medical University of South Carolina
- Study coordinator: Thomas, Bobby
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.