Modeling and treating HIV-related lung infections
Official title: Modeling and treating chronic HIV-induced lung infections
Funded at University of Maryland Baltimore · NIH-11470347 · Data updated 2026-11-12
A study at the University of Maryland Baltimore will explore how HIV affects lung immunity and how this leads to lung infections, with the goal of finding new ways to prevent and treat these infections in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 5, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,555,000 |
| NIH project number | 1R01HL184892-01A1 |
| Project ID | NIH-11470347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults living with HIV who are at risk for or have a history of bacterial or other respiratory infections.
✕Less likely to help
Patients without HIV or without susceptibility to respiratory infections may not benefit from this research.
What this research studies
People living with HIV are at higher risk for lung infections, including bacterial pneumonia. This project will investigate how HIV changes dendritic cell function in the lungs and how that affects responses to respiratory infections. By studying immune mechanisms and HIV-related proteins, researchers hope to uncover targets for new therapies to reduce lung infections and improve lung health in PLWH.
Why it matters
Potential benefit: If successful, the work could lead to new treatments that reduce lung infections and improve breathing for people with HIV.
How similar studies have gone: Previous work has shown immune changes in HIV can alter infection risk, but this project aims to identify specific mechanisms and targets in the lungs.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Rathinam, Chozha Vendan — University of Maryland Baltimore
- Study coordinator: Rathinam, Chozha Vendan
Related research
Other NIH-funded projects on the same topics.
-
Resilient HIV Implementation for LGBTQ Youth in Africa and Beyond
A program to help young people ages 15–24 who are at risk for or living with HIV, especially sexual and gender minority youths, access better HIV prevention and care through real-world health practice improvements.
-
Algorithms to find HLA-E neoantigens for cancer immunotherapy
Aims to develop computer methods to discover tumor-specific targets presented by HLA-E to guide new T cell therapies for cancer.
-
NPRL2 loss and focal cortical dysplasia in epilepsy
This grant investigates how losing NPRL2 in the brain contributes to focal cortical dysplasia and epilepsy in children.
-
New way to make head and neck cancer treatments work better
A research project at the University of Maryland Baltimore aims to improve treatment for advanced head and neck cancer, with a focus on making cisplatin and newer therapies work better while reducing kidney side effects.
-
Genetics and function of inherited brain disorders that affect thinking and behavior
Scientists are studying how genes and cellular helpers shape brain development and why certain kids have intellectual disabilities and adaptive-behavior challenges.
-
Finding broadly protective antibodies against Crimean-Congo Hemorrhagic Fever
Researchers will study blood from people who survived CCHF to find human antibodies that protect against multiple virus variants, with early tests in animal models to check their breadth.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.