Milrinone to Reduce Post-Procedure Instability in Extremely Preterm Infants

Who could benefit from this research

What this research studies

This project aims to determine if early milrinone can reduce post-procedure instability after PDA closure in the most premature infants. It builds on early data suggesting milrinone may support heart function and stabilize blood pressure and respiration during a critical time. The study uses a UH3 framework to coordinate multicenter efforts, monitor safety, and collect outcomes related to respiratory and neurodevelopmental trajectories. Parents and clinicians may gain a clearer path to safer procedures and better short- and long-term outcomes for ELBW infants.

Why it matters

Where this research is happening

• University of Iowa
  Iowa City, United States Active

Researchers

• Principal investigator: Mcnamara, Patrick J — University of Iowa
• Study coordinator: Mcnamara, Patrick J

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.