Milrinone to Prevent Post-Operative Heart-Surgery Problems in Extremely Preterm Babies
Official title: 2/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) - DCC Resubmission
Funded at Research Triangle Institute · NIH-11385461 · Data updated 2026-11-12
A randomized trial will test whether giving milrinone to extremely premature babies helps prevent serious heart and lung problems after surgical closure of a patent ductus arteriosus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,166,949 |
| NIH project number | 5U24HL166580-03 |
| Project ID | NIH-11385461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are extremely preterm infants requiring PDA ligation who are at risk for Post-Ligation Cardiac Syndrome.
✕Less likely to help
Infants not undergoing PDA ligation or those with contraindications to milrinone may derive no benefit.
What this research studies
This trial focuses on very preterm infants who need PDA surgery. It will test if giving milrinone before or during the perioperative period can reduce Post-Ligation Cardiac Syndrome and improve overall outcomes. The study relies on multicenter collaboration and rigorous randomization to compare milrinone against standard care. Results could guide treatment for preventing post-surgical instability in these vulnerable infants.
Why it matters
Potential benefit: If successful, milrinone could reduce postoperative instability and improve survival and recovery for extremely preterm babies undergoing PDA ligation.
How similar studies have gone: Preliminary data suggest milrinone may reduce PLCS in neonates, but no large randomized trials have established efficacy.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Das, Abhik — Research Triangle Institute
- Study coordinator: Das, Abhik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.