How different exercise intensities affect hunger hormones in people with obesity and prediabetes
Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status
This study looks at how different levels of exercise affect a hormone called ghrelin, which helps control hunger and energy, in both lean and obese adults, including those with prediabetes, to see how exercise can help improve health and manage appetite.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10661601 on NIH RePORTER |
What this research studies
This research investigates how varying levels of exercise intensity influence the release of ghrelin, a hormone that regulates appetite and energy balance, in both lean and obese adults, including those with prediabetes. By examining the effects of exercise on different forms of ghrelin, the study aims to understand how these hormones interact and how they can be manipulated to improve metabolic health. Participants will engage in exercise sessions while their hormone levels are monitored, providing insights into the relationship between physical activity and appetite regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are either lean or obese and may have prediabetes.
Not a fit: Patients who are not adults or do not have issues related to obesity or prediabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity and prediabetes through tailored exercise programs.
How similar studies have performed: While some studies have explored the relationship between exercise and ghrelin, this research aims to provide a more comprehensive understanding of the different forms of ghrelin and their responses to exercise intensity, making it a novel approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Weltman, Arthur — University of Virginia
- Study coordinator: Weltman, Arthur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.